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Want to hold on to -- or recapture -- your youth? These simple steps promise maximum vitality. Experts on aging agree -- there are positive steps you can take to make your "golden years" healthier and more enjoyable. And, they might just add as much as a decade or more to your life...
And what about the other substance -- a steroid called DHEA -- often recommended for aging? "Dramatically less evidence than HGH!" exclaims Blackman. As for estrogen and progesterone replacement, it's been in all the papers. The combo therapy may increase, rather than cut, the risk of cancer and heart disease.
"Retirement is a contagious, debilitating disease." Take some time off for a vacation and smell the roses, she advises. But don't get so intoxicated by the roses that you don't come back and do something useful. "Those roses could turn into daisies," she says, "as in pushing up daisies." © 2002 Web, MD, Inc.
Fifteen years ago, scientists made a stirring discovery when they demonstrated that they could reverse the process of aging in cells. By activating a set of four factors in the DNA, they reset the cell’s clock to zero, reverting adult cells to their embryonic state. The factors were named Yamanaka factors after their discoverer, Shinya Yamanaka, and a few years later, they earned him a Nobel Prize.
A cell that is zero days old can’t send an electrical nervous signal or produce collagen, nor carry on any other function. Like a stem cell, it is nothing more than a blob of potential. To overcome this, scientists have been tinkering with the timing and looking for ways to halt the reverse-aging process at the precise moment before the cell reverts to its embryonic form.
The activation of the Yamanaka factors can cause cancer, and it is still unclear whether this process will work in other cell types. “There are still so many unknowns,” she says. Reik echoes these concerns and has plans to develop safer strategies. He thinks by better pinpointing how Yamanaka factors work, he will be able to find downstream molecules that are turned on by the genetic factors.
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March 7, 2022 March 7, 2022 LA JOLLA—Age may be just a number, but it’s a number that often carries unwanted side effects, from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. Now, scientists at the Salk Institute, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states.
In 2016, Izpisua Belmonte’s lab reported for the first time that they could use the Yamanaka factors to counter the signs of aging and increase life span in mice with a premature aging disease. More recently, the team found that, even in young mice, the Yamanaka factors can accelerate muscle regeneration.
And a third group was treated for just one month at age 25 months, similar to age 80 in humans. “What we really wanted to establish was that using this approach for a longer time span is safe,” says Pradeep Reddy, a Salk staff scientist and co-first author of the new paper.
Moreover, the team found no cancers in any of the groups of animals. From left: Juan Carlos Izpisua Belmonte and Pradeep Reddy.Click here for a high-resolution image. Credit: Salk Institute When the researchers looked at normal signs of aging in the animals that had undergone the treatment, they found that the mice, in many ways, resembled younger animals.
When injured, the skin cells of treated animals had a greater ability to proliferate and were less likely to form permanent scars—older animals usually show less skin cell proliferation and more scarring. Moreover, metabolic molecules in the blood of treated animals did not show normal age-related changes. This youthfulness was observed in the animals treated for seven or 10 months with the Yamanaka factors, but not the animals treated for just one month.
Researchers discovered that supplementing a diet with the sea organisms Ascidiacea, also known as sea squirts, reverses some of the main signs of aging in an animal model. While the Fountain of Youth, the mythical spring that restores youth to anyone who bathes in it or drinks its waters, is clearly fantasy, scientists are hard at work looking for ways to combat aging.
While more research is needed to verify the effect in humans, as the study was conducted using mice, the findings are very promising. If you’ve ever glanced in the mirror and seen greying hair and wrinkles, or if you’ve forgotten the name of a close friend, you may desire a medication that might halt or even reverse the effects of aging.
Credit: Prilfish Making new connections The effects of the plasmalogen supplement on learning and memory were evaluated by training mice to navigate a Morris water maze, which consists of a pool of water with a platform that acts as a resting place. Mice typically dislike swimming, so after five days of training, they remember where the platform is and swim directly to it as soon as they enter the pool.
Astonishingly, when fed with plasmalogens, aged mice perform more like young mice, finding the platform much quicker than the control group of aged mice that have not been given the supplement. To find the reason for the improvement shown by plasmalogen-fed mice, the researchers took a closer look at changes happening within the brain.
Table of Contents
How To Reverse Aging - How To Get Younger
Things To Know About The Aging Process
How To Reverse Your Biological Age